Generic Zithromax Dispersible (Azithromycin)

Introduction

Zithromax Dispersible is a medication designed to treat a variety of bacterial infections. It contains the active ingredient Azithromycin, which belongs to a class of antibiotics called macrolides. This dispersible tablet formulation allows for easy administration, particularly for individuals who have difficulty swallowing standard tablets. Azithromycin is effective against a broad spectrum of bacteria and is used in adults and, in some cases, children to combat infections affecting the respiratory tract, skin, and other body systems.

Quick Reference Facts

Active Ingredient

Azithromycin

Form

Dispersible tablet, 100mg

Primary and Off-Label Uses

Bacterial infections, community-acquired pneumonia, acute exacerbations of COPD, strep throat, skin infections, certain sexually transmitted infections, pelvic inflammatory disease, otitis media, chlamydia, gonorrhea, and some types of prophylaxis.

What is Zithromax Dispersible?

Zithromax Dispersible is a branded generic medication containing the active compound Azithromycin. Azithromycin is an antibiotic that works by interfering with the ability of bacteria to produce essential proteins, thereby inhibiting their growth and spread. As a dispersible tablet, this formulation dissolves in water, creating a liquid suspension that can be easily swallowed. This makes it a convenient option for patients who have difficulty swallowing solid pills, including children and some adults. Zithromax Dispersible is the generic equivalent of medications previously marketed under brand names such as Zithromax, and it provides an accessible and cost-effective way to obtain Azithromycin for treating various bacterial infections.

How Azithromycin Works

Azithromycin, the active ingredient in Zithromax Dispersible, functions as a bacteriostatic antibiotic, meaning it inhibits bacterial growth and reproduction. It achieves this by binding to the 50S ribosomal subunit of susceptible bacteria. This binding action specifically prevents the translocation step of peptide chain elongation, a critical process for protein synthesis within bacterial cells. By disrupting protein production, Azithromycin effectively halt bacterial proliferation and allows the body's immune system to clear the infection. Azithromycin is characterised by its excellent tissue penetration and a pharmacokinetic profile that allows for once-daily dosing and a shorter treatment course compared to many other antibiotics. The drug is well-absorbed orally, and its elimination from the body is primarily through biliary excretion, with a long half-life that contributes to its sustained therapeutic levels.

Conditions Treated with Zithromax Dispersible

Zithromax Dispersible, containing Azithromycin, is approved for the treatment of a range of bacterial infections. Its broad-spectrum activity makes it effective against many Gram-positive and Gram-negative bacteria, as well as atypical organisms.

• Respiratory Tract Infections: This includes infections such as community-acquired pneumonia, acute bacterial sinusitis, and acute exacerbations of chronic obstructive pulmonary disease (COPD). Azithromycin is chosen for these conditions due to its efficacy against common respiratory pathogens like Streptococcus pneumoniae and Haemophilus influenzae, and its favourable penetration into lung tissues.
• Skin and Soft Tissue Infections: Azithromycin is effective against susceptible bacteria commonly found in skin infections, including Staphylococcus aureus and Streptococcus pyogenes. It is used for conditions such as impetigo and cellulitis.
• Sexually Transmitted Infections (STIs): It is a key treatment for uncomplicated chlamydial infections (Chlamydia trachomatis), often administered as a single dose. It also plays a role in the management of gonococcal infections and non-gonococcal urethritis.
• Pharyngitis/Tonsillitis: For bacterial pharyngitis caused by Streptococcus pyogenes in patients allergic to penicillin, Azithromycin is an alternative option and is effective in eradicating the bacteria.
• Otitis Media (Middle Ear Infection): Azithromycin is used to treat acute otitis media caused by specific bacteria, offering a valid alternative to other antibiotic classes.
• Prophylaxis: In certain circumstances, Azithromycin is used for prophylaxis against specific infections, such as preventing disseminated Mycobacterium avium complex (MAC) infection in patients with advanced HIV/AIDS, though this use is less common with newer treatment guidelines.

Is Zithromax Dispersible the Right Medication for You?

Zithromax Dispersible, containing Azithromycin, is a suitable treatment option for individuals diagnosed with bacterial infections against which Azithromycin is effective. Its unique dispersible formulation makes it particularly appropriate for:

• Adults and Children with Dysphagia: Those who experience difficulty swallowing standard pills or capsules will find the dispersible tablet format a more manageable and comfortable way to take their antibiotic.
• Patients Requiring Shorter Treatment Courses: For many indicated infections, Azithromycin can be administered over a shorter duration (often 3-5 days), which can improve patient adherence and reduce the risk of side effects.
• Individuals Allergic to Penicillin: For specific infections, such as strep throat caused by Streptococcus pyogenes, Azithromycin serves as an effective alternative for individuals with a penicillin allergy.

However, Zithromax Dispersible is not appropriate for everyone. It is contraindicated in patients with a known history of hypersensitivity to Azithromycin, erythromycin, or any other macrolide antibiotic. Additionally, because it is an antibiotic, it is only effective against bacterial infections and will not treat viral infections like the common cold or flu. Your doctor will assess your specific condition, medical history, and potential allergies to determine if Azithromycin is the most appropriate antibiotic for you.

Buying Zithromax Dispersible from Our Online Pharmacy

For individuals seeking convenient and accessible ways to manage their health, our online pharmacy offers a reliable solution for obtaining important medications like Zithromax Dispersible. We understand that accessing medications can sometimes be challenging due to availability, cost, or personal circumstances, and our service is designed to streamline this process.

Why Choose Our Service?

Our service aims to provide a straightforward and efficient pathway to acquire medications essential for your well-being. We focus on making it easier for patients to secure treatments they might find difficult to obtain through conventional channels, ensuring that managing your health concerns is as uncomplicated as possible.

Quality & Safety Assurance

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Use: Dosing, Missed Dose, Overdose

The appropriate use of Zithromax Dispersible (Azithromycin) is crucial for effective treatment and safety.

• Dosing: Standard dosing varies by indication. For most common infections in adults, a typical course might involve 500mg on the first day followed by 250mg daily for the next four days, or a single 1-gram dose for uncomplicated chlamydial infections. For conditions like acute otitis media or community-acquired pneumonia, dosages are often adjusted based on age and weight. Specific instructions will be provided by your healthcare provider based on your diagnosis.
• Missed Dose: If you miss a dose of Zithromax Dispersible, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not take a double dose to make up for a missed dose. If you are unsure about how to proceed, consult your doctor or pharmacist.
• Overdose: In the event of an overdose, seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, diarrhoea, and temporary auditory disturbances. It is important to contact your local poison control centre or emergency services for guidance.
• Precautions: Zithromax Dispersible should be taken with water, and the tablet should be dispersed thoroughly in the water before drinking. It can be taken with or without food. Avoid consuming large quantities of alcohol while taking Azithromycin, as it may exacerbate certain side effects like dizziness or stomach upset. Exercise caution if operating machinery or driving, as Azithromycin can cause dizziness or affect vision in some individuals.

Safety Information

⚠️ Who Should Not Take Zithromax Dispersible

Zithromax Dispersible (Azithromycin) is contraindicated in individuals with a known hypersensitivity to Azithromycin, erythromycin, any other macrolide antibiotic, or any inactive ingredient in the product. Caution is advised in patients with myasthenia gravis, as Azithromycin has been reported to exacerbate symptoms. Long-term use may lead to superinfection by non-susceptible organisms, including fungi.

Common Side Effects

Common side effects of Azithromycin are generally mild and transient. These can include:

• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain
• Headache
• Dizziness

These effects often resolve on their own as your body adjusts to the medication. If they persist or become bothersome, consult your healthcare provider.

Serious Side Effects (Seek Immediate Medical Help)

While rare, some side effects of Azithromycin can be serious and require immediate medical attention. Contact your doctor or go to the nearest emergency room if you experience any of the following:

• Severe allergic reactions: Symptoms include rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.
• Severe diarrhoea: This may be a sign of Clostridioides difficile associated diarrhoea (CDAD), which can range from mild diarrhoea to fatal colitis.
• Liver problems: Symptoms may include jaundice (yellowing of the skin or eyes), dark urine, severe stomach pain, or persistent nausea/vomiting.
• Heart rhythm abnormalities: Especially in individuals with pre-existing heart conditions, Azithromycin can potentially affect heart rhythm, leading to symptoms like chest pain, rapid heartbeat, or fainting.
• Changes in vision or hearing.

Drug & Food Interactions

Azithromycin may interact with certain other medications, potentially altering their effectiveness or increasing the risk of side effects. It is crucial to inform your doctor about all medications you are taking, including prescription drugs, over-the-counter medicines, and herbal supplements. Significant interactions include:

• Antacids: Taking certain antacids concurrently with Azithromycin can decrease its absorption. It is generally recommended to take Azithromycin at least one hour before or two hours after antacids.
• Warfarin: Azithromycin may enhance the anticoagulant effect of warfarin, increasing the risk of bleeding.
• Digoxin: Azithromycin can increase the blood levels of digoxin, a heart medication, potentially leading to toxicity.
• Theophylline: There is a potential for increased levels of theophylline, a medication used for asthma and COPD, when taken with Azithromycin.
• Ergotamine and Dihydroergotamine: Co-administration with Azithromycin may lead to ergot toxicity.
• Cisapride, Cyclosporine, Phenytoin, and Triazolam: Potential for altered blood levels of these medications.

Regarding food, Azithromycin dispersible tablets can be taken with or without food. However, it is advisable to avoid large quantities of alcohol.

Off-Label and Investigational Uses of Azithromycin

While Zithromax Dispersible (Azithromycin) is approved for specific bacterial infections, clinical studies and some medical practices have explored its use for other conditions, often referred to as off-label uses. These uses have not undergone the same rigorous regulatory approval process as the approved indications.

• Prophylaxis of Recurrent Rheumatic Fever: In patients with a history of rheumatic fever, Azithromycin has been investigated as a prophylactic agent to prevent recurrence, particularly in cases where penicillin allergy is a concern.
• Treatment of Certain Malarial Infections: In combination with other drugs, Azithromycin has been studied for its role in malaria treatment or chemoprophylaxis in specific geographical regions or patient populations, particularly against strains resistant to other antimalarials.
• Pneumocystis Pneumonia (PCP) Prophylaxis in HIV/AIDS: While trimethoprim-sulfamethoxazole is the standard of care, Azithromycin is sometimes used as an alternative for PCP prophylaxis in individuals with HIV/AIDS who are intolerant to sulfa drugs.
• Acne Vulgaris: Low-dose, long-term therapy with Azithromycin has been used to manage severe or recalcitrant acne, owing to its anti-inflammatory properties beyond its antibacterial effects.
• Bronchiectasis and Chronic Cough: In some patients with non-cystic fibrosis bronchiectasis or unexplained chronic cough, a prolonged course of low-dose Azithromycin may be prescribed for its potential anti-inflammatory and immunomodulatory effects, although the evidence and guidelines are still evolving.

It is crucial for patients to understand that off-label use of Azithromycin should only be undertaken under the strict supervision and guidance of a qualified healthcare provider. The efficacy and safety for these unapproved indications may not be fully established.

Storage & Handling

Proper storage of Zithromax Dispersible is essential to maintain its potency and efficacy.

• Temperature: Store at room temperature, typically between 20°C and 25°C (68°F and 77°F). Avoid refrigeration.
• Moisture: Keep the medication in its original container and protect it from moisture and humidity. Do not remove tablets from their blister packs until just before use.
• Light: Protect from direct light.
• Expiry: Do not use the medication after the expiry date printed on the packaging. The expiry date refers to the last day of that month.
• Disposal: Unused or expired medication should be disposed of safely. Do not flush medication down the toilet or pour it into a drain. It is best to return unused medication to a pharmacy for proper disposal.

Frequently Asked Questions

About Using Azithromycin

• Can I take Zithromax Dispersible with dairy products? Generally, dairy products do not significantly affect the absorption of orally administered Azithromycin, unlike some other antibiotics. However, it is always advisable to check specific product information or consult with your healthcare provider if you have concerns about dietary interactions.

• How long should I continue taking Zithromax Dispersible after my symptoms improve? It is important to complete the full course of Azithromycin prescribed by your doctor, even if your symptoms improve sooner. Stopping treatment early can lead to the infection returning and may contribute to antibiotic resistance.

• What is the difference between Azithromycin and Amoxicillin? Azithromycin and Amoxicillin are both antibiotics, but they belong to different classes and have different spectrums of activity and dosing regimens. Azithromycin (a macrolide) is often effective against different bacteria and can sometimes be used for shorter treatment courses, whereas Amoxicillin (a penicillin antibiotic) is typically used for a broader range of common infections with usually longer daily courses.

Product Information

• How should I mix the Zithromax Dispersible tablet? To prepare Zithromax Dispersible, place the tablet in a glass of water (approximately 50-100ml) and allow it to disperse completely before drinking the suspension. Ensure all the dispersed medication is consumed.

• Does the taste of Azithromycin vary between brands? While the active ingredient is the same, different manufacturers may use varying inactive ingredients or excipients, which can sometimes lead to subtle differences in taste or mouthfeel. If you find the taste particularly unpleasant, speak with your pharmacist about potential alternatives.

Safety & Regulations

• Can Azithromycin affect my liver? While rare, Azithromycin has been associated with liver problems, including jaundice and hepatitis. If you experience symptoms such as yellowing of the skin or eyes, dark urine, a persistent upset stomach, or abdominal pain, seek medical attention immediately.

• Is Azithromycin safe during pregnancy or breastfeeding? Azithromycin is generally considered to be of low risk during pregnancy and breastfeeding, but it should only be used if clearly needed and prescribed by a healthcare professional who can weigh the potential benefits against the risks. Always discuss your specific situation with your doctor.

Scientific & Clinical Curiosity

• Why is Azithromycin formulated as a dispersible tablet? The dispersible tablet formulation is designed for convenience and ease of administration, particularly for patients who have difficulty swallowing solid oral dosage forms, such as children or elderly individuals. It ensures accurate dosing in an easily consumable format.

• How long does Azithromycin stay in the body? Azithromycin has a long half-life, meaning it remains in the body for an extended period after the last dose. This allows for reduced dosing frequency and shorter treatment durations compared to many other antibiotics. Significant levels can be detected in tissues for several days after treatment completion.

Glossary

Bacteriostatic

A substance that inhibits the growth or reproduction of bacteria.

Macrolide Antibiotic

A class of antibiotics characterised by a large macroscopic ring structure, which includes Azithromycin, Erythromycin, and Clarithromycin.

Ribosomal Subunit

A component of ribosomes, the cellular machinery responsible for protein synthesis. The 50S subunit is where macrolides like Azithromycin bind.

Hypersensitivity

An exaggerated or abnormal immune response to a substance that is normally harmless.

Off-Label Use

The use of a drug for an indication, dosage, or patient-population that is not officially approved by regulatory authorities.

Disclaimer

The information provided about Zithromax Dispersible is intended for general knowledge and informational purposes only. It does not constitute medical advice and cannot replace consultation with a qualified healthcare professional. All decisions regarding treatment, including any use of Azithromycin for off-label conditions, must be made under the direct supervision of a physician. We operate under the assumption that all individuals using our services are responsible adults capable of making informed health choices. Our online pharmacy service aims to provide access to medications for those who require it, offering alternatives for individuals facing accessibility or cost limitations. It is imperative to consult your doctor before commencing, altering, or discontinuing any medication regimen.