Generic Prometrium (Progesterone)

Introduction

Prometrium is a medication containing the active ingredient Progesterone, available in pill form in 100mg and 200mg dosages. It belongs to a class of drugs known as progestins, which are synthetic or naturally occurring compounds that mimic the effects of the hormone progesterone. Prometrium is primarily prescribed for hormone replacement therapy, to treat menstrual irregularities, and to support pregnancies in certain situations.

Quick Reference Facts

Active Ingredient

Progesterone

Form

Pill, 100mg | 200mg

Primary and Off-Label Uses

Hormone replacement therapy, treatment of secondary amenorrhoea, prevention of endometrial hyperplasia, support in assisted reproductive technology (ART) procedures.

What is Prometrium?

Prometrium is a brand name for medications containing the active compound Progesterone. As a branded medication, its development and initial marketing are typically associated with a pharmaceutical company that invested in bringing this specific formulation and its therapeutic uses to market. Prometrium is a progestin, a type of hormone therapy that plays a crucial role in the female reproductive system. While Prometrium is a brand name, generic versions containing Progesterone are also widely available, often at a lower cost, offering bioequivalent therapeutic benefits.

How Prometrium Works

Prometrium works by delivering synthetic or naturally derived progesterone into the body, mimicking the action of endogenous progesterone. Progesterone is a key hormone that prepares the uterus for pregnancy by thickening the endometrium (the lining of the uterus). It also plays a role in regulating menstruation and is essential for maintaining pregnancy. In hormone replacement therapy (HRT), Prometrium is often used in combination with oestrogen to counteract the proliferative effects of oestrogen on the endometrium, thereby reducing the risk of endometrial hyperplasia and cancer in postmenopausal women. For conditions involving menstrual irregularities or infertility, progesterone's role in the menstrual cycle and its luteal phase support are leveraged to restore normal hormonal balance or to aid implantation and early pregnancy. The absorption and effectiveness of Prometrium depend on factors such as formulation, dosage, and individual patient metabolism.

Conditions Treated with Prometrium

Prometrium is approved for several gynaecological conditions:

• Hormone Replacement Therapy (HRT): In postmenopausal women, oestrogen therapy can lead to excessive thickening of the uterine lining (endometrium). Prometrium is prescribed alongside oestrogen to help regulate the endometrium, reduce the risk of hyperplasia, and prevent endometrial cancer. It achieves this by counteracting the oestrogen-driven growth of the uterine lining, promoting a more balanced hormonal environment.

• Treatment of Secondary Amenorrhoea: This condition refers to the absence of menstruation in women who have previously had periods. Prometrium can be used to induce a withdrawal bleed by first building up the uterine lining and then stopping the progesterone, simulating the natural hormonal fluctuations that trigger menstruation.

• Prevention of Endometrial Hyperplasia: As mentioned in HRT, Prometrium is crucial in preventing the overgrowth of the uterine lining, which can be a precursor to uterine cancer, particularly when women are receiving oestrogen therapy.

• Support in Assisted Reproductive Technology (ART): In procedures like in vitro fertilisation (IVF), Prometrium is often used to prepare the uterine lining for implantation of an embryo and to support the early stages of pregnancy following embryo transfer. Its role is to ensure the endometrium is receptive for implantation and to create a stable environment for early foetal development.

Is Prometrium the Right Medication for You?

Prometrium is generally considered for adult women who require progesterone supplementation or replacement therapy. This includes postmenopausal women undergoing hormone replacement therapy who still have a uterus and require protection against endometrial hyperplasia. It is also indicated for women experiencing secondary amenorrhoea where hormonal imbalance is the cause. Furthermore, individuals undergoing assisted reproductive technology treatments may be candidates for Prometrium to enhance the chances of successful implantation and pregnancy.

Contraindications for Prometrium include known hypersensitivity to progesterone, undiagnosed vaginal bleeding, known or suspected pregnancy (though sometimes used to support pregnancy, it is contraindicated if pregnancy is causing the bleeding or in cases of miscarriage), history of blood clots (thrombophlebitis, thromboembolic disorders), severe liver disease, and known or suspected cancer of the breast or reproductive organs. It is essential to discuss your complete medical history with your healthcare provider to determine if Prometrium is appropriate for your specific needs and medical profile.

Buying Prometrium from Our Online Pharmacy

For many individuals, accessing essential medications like Prometrium can present challenges related to cost or availability. Our online pharmacy aims to alleviate these concerns by providing a reliable and convenient purchasing option, making it easier for you to manage your health effectively.

Why Choose Our Service?

We understand that acquiring prescription medications can sometimes be a complex and costly process. Our service is dedicated to simplifying this experience by offering access to high-quality medications, including Prometrium, at competitive prices. We strive to be a valuable resource for patients seeking affordable and accessible treatment options without compromising on their health or well-being.

Quality & Safety Assurance

We partner with licensed international pharmacies to ensure quality and authenticity. All medications sourced through our platform are from reputable suppliers who adhere to stringent international pharmaceutical standards and regulatory requirements. This commitment to quality assurance means you can trust the medications you receive to be genuine and effective.

Pricing & Access

One of the primary benefits of using our online pharmacy is the potential for significant cost savings. We offer Prometrium at prices that aim to be considerably lower than those found through traditional channels. This is particularly beneficial for patients who may not have prescription drug coverage or who are looking for more economical choices, such as generic alternatives if available. We facilitate access to medications that might otherwise be difficult to obtain.

Discreet Delivery

We recognise the importance of privacy and discretion for all our customers. Your medication is packaged discreetly, with no outward indication of the contents, and delivered directly to your doorstep. Whether you choose our express delivery, which typically arrives within 7 days, or our standard airmail service, with delivery in approximately 3 weeks, your privacy is paramount throughout the process.

Use: Dosing, Missed Dose, Overdose

Standard Dosing

The typical dosage of Prometrium (Progesterone) will vary depending on the specific condition being treated and the physician's assessment. For hormone replacement therapy, common dosages might include 100mg taken orally once daily for 12 to 14 days of a 28-day cycle, or 200mg taken orally once daily for the last 12 to 14 days of a 28-day cycle. For secondary amenorrhoea, similar dosing schedules may be used. When used in ART, specific protocols will be provided by the fertility clinic. It is crucial to follow the exact instructions provided by your healthcare provider.

Missed Dose

If you miss a dose of Prometrium, take it as soon as you remember, unless it is close to the time for your next scheduled dose. If it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you are unsure about what to do, consult your healthcare provider or pharmacist.

Overdose

In the event of a Prometrium overdose, symptoms may include drowsiness, dizziness, nausea, or vomiting. If you suspect an overdose, seek immediate medical attention or contact a poison control centre. While overdosing on progesterone is generally not acutely life-threatening, it can lead to unpleasant side effects and potentially disrupt hormonal balance.

Practical Precautions

With Food: Prometrium is typically taken with food to enhance absorption and minimise potential gastrointestinal upset. Alcohol: It is advisable to limit or avoid alcohol consumption while taking Prometrium, as it may increase side effects such as dizziness and drowsiness. * Operating Machinery: Due to potential side effects like dizziness and drowsiness, caution should be exercised when operating heavy machinery or driving until you know how Prometrium affects you.

Safety Information

⚠️ Who Should Not Take Prometrium

Prometrium is contraindicated in individuals with the following conditions:

• Known hypersensitivity or allergy to Progesterone or any inactive ingredients in the formulation.
• Undiagnosed vaginal bleeding, which could indicate a more serious underlying condition.
• Known or suspected pregnancy; while used in some pregnancy support scenarios, it is not for general use when pregnancy status is uncertain or when bleeding is present.
• History of or current venous thromboembolic disorders, such as deep vein thrombosis (DVT), pulmonary embolism (PE), or blood clots.
• History of arterial thromboembolic disease (e.g., stroke, heart attack).
• Severe liver dysfunction or known liver disease.
• Known or suspected carcinoma of the breast or reproductive organs (e.g., uterine cancer, ovarian cancer).
• Missed abortion or ectopic pregnancy.

Common Side Effects

Some individuals may experience side effects when taking Prometrium. These are often mild and may decrease as your body adjusts to the medication. Common side effects include:

• Drowsiness or sleepiness.
• Dizziness.
• Nausea.
• Headache.
• Abdominal pain or cramps.
• Breast tenderness.
• Mood changes or irritability.

If these effects are severe or persistent, it is important to consult with a healthcare provider.

Serious Side Effects (Seek Immediate Medical Help)

Although rare, serious side effects can occur. Seek immediate medical attention if you experience any of the following:

• Signs of a blood clot: Sudden shortness of breath, chest pain, severe headache, changes in vision, leg pain or swelling.
• Liver problems: Yellowing of the skin or eyes (jaundice), dark urine, severe abdominal pain, persistent nausea or vomiting.
• Allergic reaction: Rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, trouble breathing.
• Depression: New or worsening mood changes, thoughts of self-harm.

Prompt medical intervention is crucial if these symptoms arise.

Drug & Food Interactions

Prometrium can interact with certain medications and foods, potentially altering its effectiveness or increasing the risk of side effects.

• CYP3A4 Inhibitors: Medications that inhibit the CYP3A4 enzyme system (e.g., certain antifungals like ketoconazole, macrolide antibiotics like erythromycin, protease inhibitors) can increase the blood levels of progesterone, potentially leading to increased side effects.
• CYP3A4 Inducers: Medications that induce the CYP3A4 enzyme system (e.g., rifampicin, carbamazepine, phenytoin, St. John's Wort) can decrease the blood levels of progesterone, potentially reducing its effectiveness.
• Grapefruit Juice: Consuming large amounts of grapefruit juice may inhibit CYP3A4 enzymes, potentially increasing progesterone levels. It is generally recommended to avoid excessive grapefruit consumption while taking this medication.
• Other Medications: Always inform your healthcare provider or pharmacist about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, to check for potential interactions.

Off-Label and Investigational Uses of Prometrium

While Prometrium has several FDA-approved indications, clinical studies and observational data suggest potential off-label uses, though efficacy and safety for these applications are not formally established by regulatory bodies.

• Premenstrual Syndrome (PMS): Some healthcare providers may prescribe progesterone in the luteal phase of the menstrual cycle to help alleviate symptoms of PMS, such as mood swings, irritability, and bloating. The rationale is that progesterone may help rebalance hormonal fluctuations that contribute to PMS symptoms.

• Dysmenorrhoea (Painful Periods): In certain cases, progesterone may be used to help manage painful menstrual cramps, particularly when hormonal imbalances are suspected to be a contributing factor.

• Endometriosis Management: While not a primary treatment, progesterone may be used as part of a broader management strategy for endometriosis, aiming to suppress endometrial tissue growth outside the uterus.

• Recurrent Pregnancy Loss: For women experiencing recurrent miscarriages, especially when a luteal phase defect is suspected, progesterone therapy may be initiated under strict medical supervision to support early pregnancy.

It is crucial for patients considering Prometrium for off-label uses to understand that such treatments are not officially approved. They should only be undertaken at the discretion of and under the close supervision of a qualified healthcare provider who can monitor for both efficacy and potential adverse effects.

Storage & Handling

Prometrium pills should be stored at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F). Protect the medication from light and moisture; therefore, it should not be stored in a bathroom or near a sink. Keep the bottle tightly closed when not in use. It is important to check the expiry date on the packaging and discard any medication that has passed its expiration date or that you no longer need, following local guidelines for safe medication disposal. Do not store expired medications.

Frequently Asked Questions

About Using Prometrium

• Can Prometrium be taken with other menstrual cycle support supplements like evening primrose oil? Interactions between Prometrium and herbal supplements like evening primrose oil are not extensively documented. It is always advisable to discuss any concurrent use of supplements with your healthcare provider or pharmacist to ensure safety and efficacy.

• How should I manage taking Prometrium if I travel across multiple time zones? If you are travelling across time zones, try to maintain your usual dosing schedule as closely as possible by adjusting to the local time at your destination. Consult your healthcare provider for specific advice on timing adjustments for prolonged travel.

Product Information

• What are the inactive ingredients in Prometrium pills? The inactive ingredients in Prometrium pills typically include sesame oil, gelatin, and glycerin. Specific formulations may vary slightly, so it is advisable to check the product packaging or consult your pharmacist for a definitive list.

• Are Prometrium pills scored for easy splitting if a lower dose is needed? Prometrium pills are generally not scored and are not intended to be split. If a dose lower than 100mg is required, you should consult your healthcare provider, as a different formulation or alternative medication may be more appropriate.

Safety & Regulations

• Are there any specific precautions for older adults taking Prometrium? Older adults may be more sensitive to the side effects of hormone therapies, including Prometrium. Close monitoring of blood pressure, cognitive function, and potential for falls due to dizziness is recommended. Discuss any pre-existing health conditions with your doctor.

• Can Prometrium affect the results of medical tests? Progesterone can influence certain laboratory tests, including hormone levels and liver function tests. It is important to inform the laboratory personnel and your doctor that you are taking Prometrium before undergoing any medical tests.

• What are the implications if Progesterone (the active ingredient in Prometrium) is detected in drug tests? Progesterone is a naturally occurring hormone, and its presence in drug tests would typically be expected if you are taking Prometrium. It is not usually a substance tested for in standard drug screenings for illicit substances, but might be monitored in specific clinical diagnostic tests.

Scientific & Clinical Curiosity

• What is the difference between micronised progesterone and other forms of synthetic progestins? Micronised progesterone, as found in Prometrium, is a specific type of progesterone preparation. It is processed into very fine particles to improve absorption when taken orally. Other synthetic progestins may have different chemical structures and metabolic pathways, leading to variations in their effects and side effect profiles.

• Was Prometrium developed from natural progesterone or is it entirely synthetic? Prometrium contains micronised progesterone, which is typically derived from natural sources, such as yams. It is then processed to create the specific formulation used in the medication.

Glossary

Endometrium

The inner lining of the uterus, which thickens during the menstrual cycle in preparation for potential pregnancy.

Amenorrhoea

The absence of menstruation, which can be primary (never having menstruated) or secondary (cessation of periods after they have previously occurred).

Hormone Replacement Therapy (HRT)

Medical treatment used to alleviate menopausal symptoms by replacing hormones like oestrogen and progesterone that decline during menopause.

Endometrial Hyperplasia

A condition characterised by excessive thickening of the endometrium, which can increase the risk of uterine cancer if not managed.

CYP3A4

A key enzyme in the liver responsible for metabolising many drugs. Inhibitors or inducers of this enzyme can affect the concentration of certain medications in the body.

Disclaimer

The information provided regarding Prometrium is intended for general informational purposes only and does not constitute professional medical advice. It is essential to consult with a qualified healthcare provider for any health concerns or before making any decisions related to your treatment. All medical decisions, including the use of Prometrium for approved or off-label indications, must be made under the direct supervision of a competent healthcare professional. We operate under the assumption that individuals using our service are responsible adults capable of understanding and acting upon medical guidance. Our online pharmacy service aims to provide convenient access to medications such as Prometrium for those who may face challenges with traditional procurement channels, including cost or availability. Before commencing, altering, or discontinuing any medication, it is imperative to seek professional medical consultation.