Generic Poxet (Dapoxetine )

Introduction

Poxet is a medication used to treat premature ejaculation (PE) in adult men. It contains the active ingredient Dapoxetine, a selective serotonin reuptake inhibitor (SSRI). Available as a pill in dosages of 30mg, 60mg, and 90mg, Poxet is a generic medication designed for oral administration. While primarily indicated for PE, Poxet's pharmacological properties are well-defined.

Quick Reference Facts

Active Ingredient

Dapoxetine

Form

Pill (30mg | 60mg | 90mg)

Primary and Off-Label Uses

Premature Ejaculation (PE)

What is Poxet?

Poxet is the generic version of medications containing the active compound Dapoxetine. Dapoxetine belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). It is specifically formulated for short-term treatment of premature ejaculation in adult men. Its development focused on an SSRI with pharmacokinetic properties suitable for on-demand use. Poxet is manufactured by various pharmaceutical companies that produce generic medications, offering a widely accessible option for this condition. As a generic equivalent, Poxet provides the same therapeutic benefits as the originator product containing Dapoxetine, marketed under brand names such as Priligy.

How Poxet Works

Poxet, through its active ingredient Dapoxetine, works by increasing levels of serotonin in the brain, specifically within the central nervous system. Serotonin is a neurotransmitter that plays a crucial role in mood regulation and impulse control. In the context of premature ejaculation, Dapoxetine is thought to enhance the function of the bulbocavernosus reflex, which is the reflex arc responsible for ejaculation. By modulating serotonergic pathways, Dapoxetine helps to delay the time to ejaculation. The onset of action for Dapoxetine is typically within 1 to 3 hours after ingestion, and its effects can last for several hours, though its 'short half-life' means it is primarily used for planned sexual activity rather than as a daily medication.

Conditions Treated with Poxet

Poxet is exclusively approved for the treatment of premature ejaculation (PE) in adult men.

• Premature Ejaculation (PE): This is the primary indication for Poxet. Premature ejaculation is characterized by a consistent or recurrent ejaculation with minimal sexual stimulation, occurring before or within approximately one minute after penile penetration, and causing significant distress to the individual. Poxet is effective in prolonging the time to ejaculation and improving ejaculatory control, thereby reducing the distress associated with this condition.

Is Poxet the Right Medication for You?

Poxet is indicated for adult men who experience premature ejaculation and wish to have greater control over their ejaculatory response. It is suitable for individuals who find that PE causes them significant personal distress or interpersonal difficulty. The medication is intended for on-demand use, meaning it is taken before anticipated sexual activity.

Poxet is not appropriate for men who have not been diagnosed with premature ejaculation or for those who do not experience distress related to their ejaculatory control. It is also contraindicated in individuals with a history of hypersensitivity to Dapoxetine or any of the excipients. Furthermore, men with certain medical conditions, particularly cardiovascular issues or a history of neurological disorders affecting ejaculation, should exercise caution and consult a healthcare professional.

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Use: Dosing, Missed Dose, Overdose

Dosing Information

Poxet is an oral pill taken as needed for premature ejaculation (PE). The recommended starting dose is typically 30mg, taken approximately 1 to 3 hours before anticipated sexual activity. Based on individual response and tolerability, the dosage can be increased to 60mg if the initial dose is insufficient. It is important not to exceed a maximum dose of 60mg per day or take Poxet more than once in a 24-hour period. For patients who do not adequately respond to a 60mg dose and tolerate it well, a dose of 90mg can be considered, also taken 1-3 hours before sexual activity.

Missed Dose

Poxet is designed for on-demand use, not for daily administration. Therefore, there is no concept of a "missed dose" in the traditional sense. If you forget to take Poxet before sexual activity, you should proceed with the activity without taking the medication. Do not take a dose at another time or try to "catch up" on a missed dose. You should only take Poxet when you anticipate engaging in sexual activity.

Overdose

Information regarding overdose with Poxet is limited as it is not intended for daily use. However, if a significantly higher than recommended dose is taken, symptoms of excessive SSRI effects may occur. These could include increased dizziness, drowsiness, headache, nausea, vomiting, abdominal pain, tremor, anxiety, or agitation. In the event of a suspected overdose, it is advisable to seek immediate medical attention or contact a poison control centre for guidance. Emergency medical services should be contacted if severe symptoms develop.

Practical Precautions

• Alcohol: Consumption of alcohol should be avoided when taking Poxet. Alcohol can increase the risk of side effects such as dizziness, drowsiness, and impaired judgment, potentially leading to increased risk of injury or accidents.
• Operating Machinery: Due to potential side effects like dizziness or visual disturbances, caution should be exercised when driving, operating heavy machinery, or performing tasks that require full mental alertness until you know how Poxet affects you.
• Administration: Poxet can be taken with or without food. However, taking it with a heavy meal may delay its absorption and reduce the peak concentration of the drug, potentially affecting its onset of action.

Safety Information

⚠️ Who Should Not Take Poxet

Poxet (Dapoxetine) is contraindicated in several patient groups due to safety concerns:

• Hypersensitivity: Individuals with a known hypersensitivity or allergy to Dapoxetine or any of the inactive ingredients in Poxet should not use this medication.
• Concomitant Use of Monoamine Oxidase Inhibitors (MAOIs): Patients currently taking or having recently taken MAOIs (e.g., phenelzine, tranylcypromine, moclobemide) must not use Poxet. A washout period of at least 14 days is required between discontinuing MAOIs and starting Poxet, and at least 7 days between discontinuing Poxet and starting an MAOI.
• Other Potentially Interacting Medications: Poxet should not be used concurrently with thioridazine, other antipsychotics with high affinity for dopamine D2 receptors, or other SSRIs, serotonin-norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs) that have been approved for depression, due to the risk of serotonin syndrome. A washout period of 14 days is required.
• History of Mania or Severe Depression: Patients with a history of manic episodes or severe depression should not use Poxet. Use in patients with active suicidal ideation or attempts for depression is also a contraindication.
• Significant Cardiovascular Conditions: Individuals with unstable heart conditions such as heart failure, certain arrhythmias, or valvular heart disease should avoid Poxet. Caution is also advised for individuals with a history of syncope (fainting).
• Severe Hepatic Impairment: Poxet is not recommended for patients with moderate to severe liver impairment.

Common Side Effects

The following side effects are commonly reported with Poxet (Dapoxetine) use, typically mild to moderate in severity:

• Nausea
• Dizziness
• Headache
• Diarrhoea
• Insomnia (difficulty sleeping)
• Fatigue

These effects often diminish with continued use or can be managed. If nausea occurs, taking Poxet with water or food may help. Dizziness can usually be mitigated by avoiding sudden postural changes.

Serious Side Effects (Seek Immediate Medical Help)

While less common, serious side effects can occur. Seek immediate medical attention if you experience any of the following:

• Syncope (Fainting): This can occur during or shortly after taking Poxet, especially if combined with alcohol or in individuals with pre-existing cardiovascular conditions. The exact cause is not always determined but may relate to a vasovagal response.
• Orthostatic Hypotension: Sudden drops in blood pressure upon standing, leading to dizziness or lightheadedness.
• Serotonin Syndrome: A potentially life-threatening condition resulting from excessive serotonin levels. Symptoms can include agitation, hallucinations, rapid heartbeat, high fever, excessive sweating, shivering, muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhoea.
• Allergic Reactions: Symptoms such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.
• Hypomania or Mania: In susceptible individuals, SSRIs can induce manic or hypomanic episodes.

Drug & Food Interactions

• MAOIs (Monoamine Oxidase Inhibitors): As mentioned, concomitant use is contraindicated due to the risk of serotonin syndrome. A significant washout period is necessary.
• Other Serotonergic Drugs: Using Poxet with other drugs that increase serotonin levels, such as other SSRIs, SNRIs, triptans, St. John's Wort, or certain pain medications (tramadol), can increase the risk of serotonin syndrome.
• Thioridazine: Concurrent use with Poxet is contraindicated as it can prolong the QT interval, potentially increasing the risk of serious cardiac arrhythmias.
• CYP3A4 Inhibitors: Moderate to potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, saquinavir) can increase Dapoxetine plasma concentrations, potentially increasing the risk or severity of adverse reactions. Their concomitant use should be approached with caution.
• CYP2D6 Inhibitors: Potent CYP2D6 inhibitors can also increase Dapoxetine concentrations, requiring dose adjustments.
• Tamsulosin: Concurrent use of Poxet with tamsulosin can lead to an increased risk of orthostatic hypotension.
• Alcohol: As previously noted, alcohol consumption should be avoided due to increased risk of dizziness and potential syncope.
• Nitrates: Combined use of Poxet with nitrates (including recreational ones like amyl nitrite or "poppers") is not recommended due to the potential for a significant drop in blood pressure, leading to dizziness and fainting.

Off-Label and Investigational Uses of Poxet

While Poxet (Dapoxetine) is specifically approved for the on-demand treatment of premature ejaculation (PE) in adult men, its pharmacological profile as an SSRI has led to some investigation and off-label use in related contexts.

• Generalized Anxiety Disorder (GAD): SSRIs, including Dapoxetine, are standard treatments for GAD. However, the pharmacokinetic profile of Dapoxetine, with its rapid absorption and short half-life, makes it largely unsuitable for daily treatment of chronic anxiety disorders compared to SSRIs designed for long-term use. Clinical studies have not established Poxet as a primary treatment for GAD compared to other SSRIs.
• Other Ejaculatory Dysfunctions: In some clinical settings, Dapoxetine may be considered for other forms of ejaculatory dysfunction when deemed appropriate by a healthcare professional, though its efficacy beyond PE has not been formally established or approved by regulatory bodies.

It is crucial to reiterate that any use of Poxet outside of its approved indication for premature ejaculation is considered off-label. Such uses should only be undertaken under the strict supervision of a qualified healthcare provider who can assess the potential benefits and risks based on the latest scientific evidence and individual patient circumstances.

Storage & Handling

Poxet pills should be stored in their original packaging to protect them from light and moisture. The recommended storage temperature is typically at or below 30°C (86°F), though specific instructions may vary by manufacturer. Keep Poxet out of reach and sight of children. Do not use the medication after the expiry date printed on the packaging. Expired medication should be disposed of safely; consult your pharmacist or local waste disposal authority for guidance on how to safely discard unwanted or expired pharmaceuticals.

Frequently Asked Questions

About Using Poxet

• Can I take Poxet with other medications for erectile dysfunction (ED)? If you are using medications for erectile dysfunction, it is essential to consult your doctor. While Poxet is indicated for premature ejaculation, combining it with ED medications requires careful medical assessment to ensure safety, particularly regarding blood pressure effects.

• Is it safe to take Poxet while traveling across time zones? Poxet is taken 1-3 hours before anticipated sexual activity. For travel, plan your dose accordingly based on when you expect to be sexually active. Taking it on an empty stomach may lead to a faster onset of action.

• What is the difference between Poxet and daily SSRIs for depression? Poxet contains Dapoxetine, an SSRI with a rapid onset of action and a short half-life, making it suitable for on-demand use. Daily SSRIs designed for depression have different pharmacokinetic profiles and are intended for continuous, long-term treatment to manage mood disorders.

Product Information

• What do Poxet pills look like? Poxet pills are typically round and coated. The specific appearance, including colour and markings, may vary slightly depending on the manufacturer. Always refer to the packaging for precise details.

• Can I split or crush Poxet pills? It is generally advised not to split, crush, or chew Poxet pills unless specifically instructed by a healthcare professional or noted in the patient information leaflet. The coating is often designed for controlled release or to mask taste.

Safety & Regulations

• Will Poxet show up on a drug test? Standard drug tests typically screen for illicit substances or specific prescribed drug classes like benzodiazepines or opioids. Poxet (Dapoxetine) is not usually included in typical screening panels, but specific workplace or legal requirements may vary.

• Are there any specific warnings for elderly men using Poxet? While Poxet is for adult men, its use in the elderly has not been extensively studied. Caution should be exercised due to a potential increased susceptibility to adverse events, particularly syncope and orthostatic hypotension.

Scientific & Clinical Curiosity

• When was Dapoxetine first developed? Dapoxetine was developed by Eli Lilly and Company and was initially investigated as an antidepressant. Its potential for treating premature ejaculation was later recognized due to its specific pharmacokinetic properties that allowed for on-demand use.

Glossary

Selective Serotonin Reuptake Inhibitor (SSRI)

A class of antidepressant medications that works by increasing the levels of serotonin, a neurotransmitter, in the brain.

Premature Ejaculation (PE)

A common male sexual dysfunction characterized by a rapid ejaculation, typically within one minute of vaginal penetration, that causes distress and lack of control.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolised, and excreted by the body.

Syncope

A temporary loss of consciousness caused by a sudden drop in blood pressure.

Serotonin Syndrome

A potentially dangerous condition caused by a buildup of serotonin in the body, which can occur when taking medications that affect serotonin levels.

Disclaimer

The information provided about Poxet is intended for general knowledge and informational purposes only. It does not constitute medical advice and should not be relied upon as a substitute for professional medical consultation. All decisions regarding healthcare, including decisions about starting, continuing, or changing any medication, especially for off-label uses, must be made in consultation with and under the direct supervision of a qualified healthcare provider. We operate under the assumption that all users of this information are responsible adults capable of making informed choices about their health. Our online pharmacy service aims to provide accessible options for medications like Poxet, particularly for individuals who may face challenges in obtaining them through other channels or seek cost-effective generic alternatives. It is imperative to consult your doctor or a qualified healthcare professional before making any decisions related to your health or treatment.