Generic Parlodel (Bromocriptine)

Introduction

Parlodel is a medication primarily used to treat conditions involving high levels of prolactin in the blood, such as hyperprolactinemia. It is also used to manage symptoms of Parkinson's disease and acromegaly. Parlodel is a brand name for the active ingredient bromocriptine, a dopamine agonist. It is available in pill form at dosages of 2.5mg. Parlodel belongs to a class of drugs known as ergot alkaloids, which work by mimicking the action of dopamine in the body.

Quick Reference Facts

Active Ingredient

Bromocriptine

Form

Pill 2.5mg

Primary and Off-Label Uses

Hyperprolactinemia, Parkinson's Disease, Acromegaly, Type 2 Diabetes Mellitus

What is Parlodel?

Parlodel is a prescription medication containing bromocriptine as its active ingredient. It is classified as a dopamine receptor agonist. Bromocriptine was developed by Sandoz (now part of Novartis) and has been available for several decades. Parlodel is the original brand name for bromocriptine in many markets. As bromocriptine is now off-patent, generic versions are widely available, often at a lower cost, offering the same therapeutic benefits. These generic alternatives are bioequivalent to Parlodel, meaning they work in the same way and to the same extent in the body.

How Bromocriptine Works

Bromocriptine functions by simulating the action of dopamine, a neurotransmitter that plays a crucial role in regulating various bodily functions, including hormone release, movement, and mood. In conditions like hyperprolactinemia, high levels of prolactin are often caused by tumours on the pituitary gland that interfere with dopamine's natural inhibitory effect. Bromocriptine, by activating dopamine receptors (specifically D2 receptors), effectively reduces prolactin secretion from the pituitary gland. In Parkinson's disease, dopamine levels are deficient in the brain; bromocriptine helps to compensate for this deficiency by directly stimulating dopamine receptors, thereby improving motor control. For acromegaly, it helps to lower growth hormone and insulin-like growth factor 1 (IGF-1) levels.

Conditions Treated with Parlodel

Parlodel (bromocriptine) is approved for the management of several medical conditions:

• Hyperprolactinemia: This condition is characterised by elevated levels of the hormone prolactin in the blood. Prolactin is typically produced by the pituitary gland and signals the body to produce milk after childbirth. In individuals who are not pregnant or breastfeeding, high prolactin levels can lead to symptoms such as irregular menstrual cycles, infertility, galactorrhea (inappropriate milk discharge), and decreased libido. Bromocriptine's ability to block prolactin release makes it highly effective in restoring normal prolactin levels and alleviating these symptoms.

• Parkinson's Disease: Parkinson's disease is a progressive neurodegenerative disorder affecting motor function, primarily due to the loss of dopamine-producing neurons in the brain. Bromocriptine can be used alone or in combination with other Parkinson's medications, such as levodopa, to help manage motor symptoms like tremors, stiffness, and slowness of movement. By stimulating dopamine receptors, it can help to restore a degree of normal neurological signalling.

• Acromegaly: This condition results from the pituitary gland overproducing growth hormone (GH) in adulthood. This excess GH leads to the abnormal growth of bones, particularly in the hands, feet, and face, and can also cause various other health problems. Bromocriptine can help to lower GH and IGF-1 levels in some patients with acromegaly, thereby helping to control the disease's progression and associated symptoms.

Is Parlodel the Right Medication for You?

Parlodel (bromocriptine) may be a suitable treatment option for adults diagnosed with hyperprolactinemia, Parkinson's disease, or acromegaly, as recommended by their healthcare provider. It is particularly beneficial for individuals who require a medication that can enhance dopamine activity or suppress prolactin levels. Patients who have not responded adequately to other treatments or who are seeking a dopamine agonist might find bromocriptine effective.

However, Parlodel is not appropriate for everyone. Individuals with uncontrolled hypertension, a history of certain heart conditions, or known hypersensitivity to bromocriptine or other ergot derivatives should avoid this medication. It is also crucial for patients to discuss their complete medical history, including any history of psychiatric disorders, liver disease, or pregnancy, with their doctor before commencing treatment, as these conditions may necessitate caution or preclude its use.

Buying Parlodel from Our Online Pharmacy

For individuals seeking access to Parlodel or its generic equivalent, bromocriptine, our online pharmacy service offers a convenient and reliable solution. We understand that obtaining necessary medications can sometimes be challenging due to various factors, and we aim to bridge that gap for our customers.

Why Choose Our Service?

Our service is designed to provide accessible and cost-effective options for patients. We facilitate access to a wide range of medications, ensuring that you can find the treatments you need without unnecessary complications. By streamlining the acquisition process, we help you manage your health more effectively from the comfort of your home.

Quality & Safety Assurance

We partner with licensed international pharmacies to ensure quality and authenticity. All medications procured through our platform are sourced from reputable suppliers who adhere to stringent international quality and safety standards. This assurance means you can trust the integrity and efficacy of the products you receive from us.

Pricing & Access

We are committed to offering competitive pricing, often enabling substantial savings compared to local pharmacies, especially for generic medications. For bromocriptine, this means you can access an affordable and therapeutically equivalent alternative to the branded Parlodel. Our aim is to make essential treatments more attainable for everyone, reducing financial burdens associated with healthcare.

Discreet Delivery

Your privacy is paramount. We ensure that all orders are dispatched in discreet, plain packaging, with no external markings that could reveal the contents. This commitment to discretion means your personal information and medication choices remain completely private. We offer various delivery options, with express delivery typically within 7 days or standard airmail in approximately 3 weeks, ensuring your medication arrives safely and promptly.

Use: Dosing, Missed Dose, Overdose

When prescribed Parlodel (bromocriptine), adhering to the specific dosing instructions provided by your healthcare provider is essential.

• Dosing: A typical starting dose for adults with hyperprolactinemia is 2.5mg taken once daily, often at bedtime, to minimise potential side effects like nausea. The dose may be gradually increased by your doctor based on your response and tolerability. For Parkinson's disease or acromegaly, the dosing regimen can be quite different and is usually more complex. Always follow your doctor's prescribed dosage and frequency.

• Missed Dose: If you miss a dose of Parlodel, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure or frequently miss doses, discuss strategies or reminder systems with your healthcare provider.

• Overdose: Signs of an overdose can include severe nausea, vomiting, dizziness, low blood pressure, drowsiness, or even hallucinations. If you suspect an overdose, seek immediate medical attention. Contact your local emergency services or go to the nearest hospital emergency department. If possible, bring the medication packaging with you.

• Precautions: Parlodel can cause dizziness and drowsiness, so it is advisable to avoid driving or operating heavy machinery until you know how this medication affects you. Alcohol consumption may increase the risk of dizziness and drowsiness; therefore, it is best to limit or avoid alcohol while taking bromocriptine. Taking Parlodel with food can help reduce stomach upset and nausea.

Safety Information

⚠️ Who Should Not Take Parlodel

Parlodel (bromocriptine) is contraindicated in patients with:

• Known hypersensitivity or allergy to bromocriptine or any other ergot alkaloid components.
• Uncontrolled hypertension (high blood pressure).
• A history of severe cardiovascular disease.
• A history of peripheral vascular disease.
• Severe liver impairment.

It should be used with extreme caution and under strict medical supervision in patients with a history of psychiatric disorders, gastrointestinal ulcers, or recent myocardial infarction.

Common Side Effects

The most frequent side effects associated with Parlodel treatment include:

• Nausea and vomiting
• Headache
• Dizziness or light-headedness
• Low blood pressure (hypotension), especially upon standing
• Fatigue or drowsiness
• Stomach upset or abdominal pain

These symptoms are often dose-dependent and may decrease over time or with dose adjustment. Taking the medication with food can help mitigate gastrointestinal side effects.

Serious Side Effects (Seek Immediate Medical Help)

Although less common, serious side effects can occur and require immediate medical attention:

• Sudden onset of sleep: In patients treated for Parkinson's disease, a sudden, overwhelming urge to sleep can occur. This can lead to accidents.
• Fibrotic reactions: Long-term use, particularly at higher doses, may be associated with fibrotic reactions affecting the lungs, heart valves, or retroperitoneum. Symptoms can include shortness of breath, chest pain, or leg swelling.
• Psychiatric effects: Hallucinations, confusion, depression, or agitation can occur.
• Hypotension: Severe drops in blood pressure, leading to fainting or collapse.
• Allergic reactions: Rash, itching, swelling, severe dizziness, or trouble breathing.

If you experience any of these symptoms, stop taking Parlodel and contact your doctor immediately or seek emergency medical care.

Drug & Food Interactions

• Dopamine antagonists: Medications like antipsychotics (e.g., haloperidol, chlorpromazine) can reduce the effectiveness of bromocriptine.
• Erythromycin and other macrolide antibiotics: May increase bromocriptine levels, potentially increasing side effects.
• Hypertension medications: Bromocriptine can sometimes cause increased blood pressure.
• Antifungal agents (e.g., ketoconazole): Some antifungals can elevate bromocriptine levels.
• Alcohol: May potentiate dizziness and drowsiness.
• Grapefruit juice: While less common for bromocriptine than some other medications, it's always wise to discuss significant dietary changes with your doctor or pharmacist.

Off-Label and Investigational Uses of Parlodel

Beyond its approved indications, bromocriptine has been investigated or used off-label for several other conditions. It is important to note that these uses have not undergone the same rigorous regulatory approval process as the primary indications.

• Type 2 Diabetes Mellitus: Bromocriptine has been studied for its potential role in improving glycaemic control in patients with type 2 diabetes. Its proposed mechanism involves modulating circadian rhythms and improving insulin sensitivity. Some formulations are specifically approved for this indication in certain regions. Clinical studies suggest it can help lower HbA1c levels when added to existing diabetes management plans.

• Migraine Prophylaxis: In some cases, bromocriptine has been used experimentally for the prevention of certain headache disorders, though this is not a standard or approved use.

• Amenorrhea and Galactorrhea Post-Medication: While primarily used for hyperprolactinemia, bromocriptine might occasionally be used to manage persistent galactorrhea or amenorrhea that arises as a side effect of other medications, particularly certain antipsychotics.

These off-label applications should only be considered under the close supervision of a healthcare professional who can weigh the potential benefits against the risks and monitor the patient's response.

Storage & Handling

Parlodel and its generic equivalent, bromocriptine, should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F). Keep the medication in its original container, tightly closed, to protect it from moisture and light. Avoid storing it in excessive heat or direct sunlight. Do not store in the bathroom. Ensure that the medication is kept out of reach of children and pets. If you have expired medication or medication that is no longer needed, do not flush it down the toilet or pour it into a drain. Consult your local pharmacy or waste disposal service for guidance on safe disposal methods for unused or expired medications.

Frequently Asked Questions

About Using Bromocriptine

• Can I take bromocriptine with grapefruit juice? While grapefruit juice interactions are more commonly associated with other drug classes, it's always prudent to consult your healthcare provider or pharmacist regarding significant dietary changes while on bromocriptine. Specific interactions can vary.

• Is it safe to take bromocriptine while traveling across time zones? When crossing time zones, it is generally recommended to adjust your bromocriptine dosing schedule to align with the new local time. Try to maintain your usual time interval between doses as closely as possible to ensure consistent therapeutic levels.

• What should I do if I experience nausea with bromocriptine? Nausea is a common side effect. Taking bromocriptine with food, particularly a meal or snack, can significantly help in reducing this symptom. Your doctor might also suggest starting at a lower dose and gradually increasing it.

• Can I drink alcohol while taking bromocriptine? It's advisable to limit or avoid alcohol consumption, as it can increase the risk of side effects like dizziness and drowsiness, impairing your ability to perform tasks requiring alertness.

Product Information

• What do bromocriptine pills look like? Bromocriptine pills, including Parlodel, are typically small, white to off-white tablets. However, the exact appearance, including any markings or imprints, can vary between manufacturers of generic versions. Always refer to the packaging for specific details.

• Are there inactive ingredients in bromocriptine pills? Yes, like most medications, bromocriptine pills contain inactive ingredients (excipients) such as lactose, starch, and magnesium stearate. These are added for manufacturing purposes or to aid in the tablet's dissolution.

Safety & Regulations

• Will bromocriptine show up on a drug test? Bromocriptine is a prescription medication and is not typically included in standard drug screening tests unless specifically looked for. Standard drug tests for illicit substances or common prescription drugs usually do not screen for bromocriptine.

• Is bromocriptine safe to use during pregnancy? Bromocriptine is generally not recommended during pregnancy, especially for conditions unrelated to pregnancy, as it can potentially affect hormone levels. However, in specific cases like medically indicated management of hyperprolactinemia that interferes with pregnancy, it may be used under strict medical guidance. Always discuss pregnancy plans with your doctor.

• Are there any specific warnings for older adults taking bromocriptine? Older adults may be more sensitive to the side effects of bromocriptine, particularly dizziness, low blood pressure, and confusion. A lower starting dose and careful monitoring are often recommended for this population.

Scientific & Clinical Curiosity

• How quickly does bromocriptine start working? The onset of action can vary depending on the condition being treated. For prolactin reduction, effects may be noticeable within a few hours to days. For Parkinson's disease symptoms, it may take several weeks to months of consistent use to observe significant improvement.

• Is bromocriptine considered a potent dopamine agonist? Yes, bromocriptine is a potent dopamine receptor agonist, primarily acting on D2 receptors, with some activity at D1 receptors. Its potency and selective action contribute to its efficacy in managing conditions related to dopamine and prolactin regulation.

Glossary

Dopamine Agonist

A drug that mimics the effects of the neurotransmitter dopamine by binding to dopamine receptors in the brain.

Hyperprolactinemia

A condition characterised by abnormally high levels of the hormone prolactin in the blood, which can cause infertility, irregular menstruation, and milk production outside of pregnancy or breastfeeding.

Neurodegenerative Disorder

A condition that affects the structure and function of parts of the nervous system, leading to progressive loss of function. Parkinson's disease is an example.

Ergot Alkaloid

A class of compounds derived from ergot fungi, which can have various pharmacological effects, including dopamine agonism. Bromocriptine belongs to this group.

Bioequivalent

When two drugs contain the same active ingredient and are the same dosage form, strength, and route of administration, and their bioavailability is so similar that they are expected to produce the same clinical effect and safety profile.

Disclaimer

The information provided about Parlodel is for general knowledge purposes only. It is not a substitute for professional medical advice. Always consult with a qualified healthcare provider for any medical condition, diagnosis, or treatment decisions. Off-label uses of medications mentioned should only be undertaken under the direct supervision of a healthcare professional knowledgeable in such treatments. We assume all users are responsible adults capable of making informed decisions regarding their health. Our online pharmacy service provides access to medications such as Parlodel for individuals who may face challenges in obtaining them through conventional channels, such as limited availability or high costs. Always seek the advice of your doctor or other qualified health provider before starting, changing, or discontinuing any medication.