Generic Flibanserin (Flibanserin)

Introduction

Flibanserin is a medication used to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. It works by affecting neurotransmitters in the brain that can influence sexual desire. Flibanserin is available as a 100mg pill and is classified as a selective serotonin reuptake enhancer/serotonin receptor antagonist.

Quick Reference Facts

Active Ingredient

Flibanserin

Form

Pill (100mg)

Primary and Off-Label Uses

Acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.

What is Flibanserin?

Flibanserin is a medication specifically approved for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. It is a non-hormonal medication that operates by influencing brain chemicals related to mood and sexual desire. Flibanserin is the active compound, and it is available as a 100mg pill. It is a medication that is sometimes referred to as a "female Viagra," though its mechanism of action and target population differ significantly from sildenafil (Viagra). Flibanserin was developed to address a need for pharmacological interventions for lowered libido that is not situational and is distressing to the individual.

How Flibanserin Works

Flibanserin works by modulating the activity of key neurotransmitters in the brain, primarily serotonin and dopamine. It acts as a serotonin 1A receptor agonist and a serotonin 2A receptor antagonist. Additionally, it has effects on dopamine D4 receptors. By binding to these receptors, Flibanserin aims to restore a balance of these neurochemicals that may have become disrupted, leading to reduced sexual desire.

In women with HSDD, there is believed to be an imbalance in some of these neurotransmitter systems. Flibanserin does not directly increase sexual arousal but rather influences the brain pathways that are thought to be involved in promoting sexual desire. The drug's effects are believed to be systemic, meaning it works throughout the brain rather than targeting a specific organ or system. The therapeutic effects typically take several weeks to become apparent, and it is generally taken daily.

Conditions Treated with Flibanserin

Flibanserin is approved for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.

• Acquired, Generalized Hypoactive Sexual Desire Disorder (HSDD): This condition is characterised by a persistent or recurrent lack of sexual desire that causes significant distress. It is termed "acquired" because it develops after a period of normal sexual desire, and "generalized" because it applies to all sexual situations, not just specific ones or partners. Flibanserin is prescribed for women who experience this distressing lack of desire and have not been diagnosed with a medical, psychiatric, or relationship issue contributing to their low libido.

Is Flibanserin the Right Medication for You?

Flibanserin is indicated for premenopausal women diagnosed with acquired, generalized hypoactive sexual desire disorder (HSDD) who experience distress due to their low sexual desire. This medication is intended for women whose low libido is not attributable to a medical condition, psychiatric disorder, relationship issues, or the effects of other medications. Therefore, a thorough medical evaluation is necessary to determine if HSDD is the correct diagnosis and if Flibanserin is an appropriate treatment option.

Contraindications for Flibanserin include known hypersensitivity to its active ingredient or any of its excipients. It is also not recommended for women with significant hepatic impairment. Furthermore, due to potential drug interactions, its use is contraindicated with moderate or strong CYP3A4 inhibitors, as well as with alcohol. Women who have a history of depression or suicidal ideation should discuss this with their healthcare provider, as caution is advised.

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Quality & Safety Assurance

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Use: Dosing, Missed Dose, Overdose

The standard recommended dose of Flibanserin for the treatment of acquired, generalized HSDD in premenopausal women is one 100mg pill taken once daily at bedtime. It is important to take the medication exactly as prescribed by your healthcare provider and to refrain from taking more than one dose in a 24-hour period.

If you miss a dose of Flibanserin, take it as soon as you remember, provided it is at least two hours before your next scheduled dose. If it is less than two hours until your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Flibanserin at the same time to compensate for a missed dose.

In case of an overdose, seek immediate medical attention. Symptoms of an overdose may include severe dizziness, fainting, nausea, vomiting, stomach pain, or confusion. Contact your local emergency services or poison control centre immediately. It is crucial to avoid alcohol consumption while taking Flibanserin, as this can significantly increase the risk of hypotension, syncope, and central nervous system depression. Additionally, avoid driving or operating heavy machinery until you know how Flibanserin affects you, as it can cause dizziness and impaired judgment.

Safety Information

⚠️ Who Should Not Take Flibanserin

Flibanserin is contraindicated in individuals with:

• Known hypersensitivity to Flibanserin or any of its excipients.
• Significant hepatic impairment.
• Concomitant use of moderate or strong CYP3A4 inhibitors (e.g., certain antifungals, antibiotics, or protease inhibitors).
• Concomitant use of alcohol.

Flibanserin should be used with caution in patients with a history of depression or suicidal ideation.

Common Side Effects

The most frequently reported side effects associated with Flibanserin include:

• Dizziness
• Nausea
• Fatigue
• Constipation
• Insomnia
• Dry mouth
• Abnormal dreams

These side effects are usually mild to moderate and tend to improve with continued use. If they become severe or persistent, consulting with a healthcare provider is advised.

Serious Side Effects (Seek Immediate Medical Help)

Serious side effects are less common but require immediate medical attention. These include:

• Hypotension and Syncope (Fainting): This risk is significantly increased when Flibanserin is taken with alcohol or with moderate/strong CYP3A4 inhibitors. Symptoms may include lightheadedness, dizziness, or feeling like you might pass out.
• Central Nervous System (CNS) Depression: This can manifest as extreme sleepiness, difficulty staying awake, or impaired cognitive function.
• Allergic Reactions: Though rare, symptoms like rash, itching, swelling, severe dizziness, or trouble breathing warrant immediate emergency care.

Drug & Food Interactions

Flibanserin has several important interactions:

• Alcohol: Concomitant use of alcohol and Flibanserin increases the risk of hypotension, syncope, and CNS depression. It is strongly advised to avoid alcohol entirely while taking Flibanserin.
• CYP3A4 Inhibitors: Moderate and strong inhibitors of the CYP3A4 enzyme (e.g., ketoconazole, itraconazole, voriconazole, telithromycin, nefazodone, fluoxetine, paroxetine, quinidine, imatinib) can significantly increase Flibanserin blood levels, leading to a higher risk of adverse events like hypotension, syncope, and CNS depression. Thus, they are contraindicated.
• CYP1A2 Inhibitors: While less severe than CYP3A4 inhibitors, inhibitors of CYP1A2 (e.g., fluvoxamine) can increase Flibanserin exposure and should be used with caution.
• Grapefruit Juice: While not as potent as CYP3A4 inhibitors, grapefruit juice can inhibit CYP3A4. Therefore, avoiding or limiting grapefruit intake is also recommended as a precautionary measure.

Off-Label and Investigational Uses of Flibanserin

While Flibanserin is officially approved only for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women, its mechanism of action affecting neurotransmitters has led to some exploration in other areas, though these are not officially endorsed uses. Clinical studies and some anecdotal evidence have suggested potential benefits in specific populations or related conditions, but efficacy and safety for these uses have not been formally evaluated or approved by regulatory bodies.

For example, research has explored its potential in conditions where serotonergic or dopaminergic pathways are implicated, such as certain mood disorders or other forms of sexual dysfunction. However, it is crucial to note that any use of Flibanserin outside its approved indication should only be considered under the strict supervision of a qualified healthcare professional who can weigh the potential benefits against the risks and monitor the patient closely. Information on these uses is primarily derived from ongoing research and may not be widely established in clinical practice.

Storage & Handling

Flibanserin should be stored at room temperature, typically between 20°C and 25°C (68°F and 77°F). It should be protected from light and moisture. Keep the medication in its original container, tightly closed. Unused medication should be disposed of safely, ideally by returning it to a pharmacy for proper disposal, rather than flushing it down the toilet or pouring it down the drain, to prevent environmental contamination. Check the expiry date on the packaging and do not use the medication if it has passed this date.

Frequently Asked Questions

About Using Flibanserin

• Can I take Flibanserin with alcohol? No, it is strongly recommended to avoid alcohol entirely when taking Flibanserin. Alcohol significantly increases the risk of serious side effects like fainting (syncope) and severe dizziness (hypotension), as well as central nervous system depression.

• How long does it take for Flibanserin to start working? It typically takes several weeks of daily consistent use for patients to notice an improvement in their sexual desire. Some women may see benefits within four weeks, while for others it can take up to eight weeks or longer.

• Is it safe to take Flibanserin while traveling across time zones? It is best to maintain a consistent dosing schedule if possible. If you are travelling across time zones and your schedule is disrupted, try to take your dose close to your usual bedtime in the new time zone. If you miss your dose by more than two hours, skip it and take your next dose at the regular time.

Product Information

• What do Flibanserin pills look like? Flibanserin is supplied as a white to off-white, round, film-coated tablet containing 100mg of the active ingredient. Each tablet may be imprinted with specific markings.

• Do Flibanserin tablets need to be broken, cut, or chewed? No, Flibanserin should be swallowed whole. The film coating is designed to protect the medication and ensure its proper absorption or to mask an unpleasant taste. Do not crush, break, or chew the tablets.

Safety & Regulations

• Will Flibanserin show up on a drug test? Flibanserin is not a controlled substance and is not typically included in standard drug screening panels that look for illicit substances or commonly abused prescription drugs. Therefore, it is unlikely to cause a positive result on most routine drug tests.

• Are there any specific warnings for elderly patients taking Flibanserin? Flibanserin is indicated for premenopausal women. While not specifically contraindicated for older adults without a diagnosis of HSDD, its safety and efficacy in postmenopausal women or the elderly population have not been adequately studied, and it is generally not prescribed for them.

• What are the risks of taking Flibanserin for a long time? The long-term safety profile of Flibanserin is based on clinical trials of up to one year in duration. Continued use is generally considered safe for individuals who benefit from the medication and tolerate it well, but ongoing monitoring by a healthcare professional is recommended to assess continued efficacy and safety.

Glossary

Acquired Hypoactive Sexual Desire Disorder (HSDD)

A condition characterized by a persistent or recurrent lack of sexual desire that causes significant personal distress, developing after a period of normal sexual desire and not attributable to other medical, psychological, or relationship factors.

Premenopausal Women

Women who have not yet gone through menopause, typically defined as women who still have menstrual cycles and are of reproductive age.

Neurotransmitters

Chemical messengers that transmit signals from a neuron across a synapse to a target neuron, muscle cell, or gland cell. Serotonin and dopamine are examples that play roles in mood and sexual desire.

Syncope

The medical term for fainting or passing out, typically due to a temporary drop in blood flow to the brain.

CYP3A4 Enzyme

A key enzyme in the liver responsible for metabolising many medications. Inhibiting this enzyme can lead to higher levels of certain drugs in the body.

Disclaimer

The information provided about Flibanserin is for general knowledge and informational purposes only. It does not constitute medical advice and should not be relied upon as a substitute for professional medical consultation, diagnosis, or treatment. All treatment decisions regarding Flibanserin, including any considerations for off-label indications, must be made under the direct supervision and guidance of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their own health. Our online pharmacy service aims to provide accessible and cost-effective options for obtaining Flibanserin for individuals who may have limited availability through traditional pharmacies or who are seeking affordable medication alternatives. It is imperative to consult with your doctor or other qualified health professional before starting, altering, or discontinuing any medication.