Generic Clarithromycin (Clarithromycin)

Introduction

Clarithromycin is a prescription medication primarily used to treat a variety of bacterial infections. As a macrolide antibiotic, it works by inhibiting the growth of bacteria. It is available in pill form, commonly in 250mg and 500mg dosages. Beyond its main uses, Clarithromycin may also be used in combination therapy for certain eradicated gastroduodenal conditions.

Quick Reference Facts

Active Ingredient

Clarithromycin

Form

Pill (250mg | 500mg)

Primary and Off-Label Uses

Bacterial infections (respiratory, skin, ear), H. pylori eradication, atypical infections.

What is Clarithromycin?

Clarithromycin is a semi-synthetic antibiotic belonging to the macrolide class. It is the active compound in medications prescribed for bacterial infections. Clarithromycin is the generic version of medications that, for instance, were historically marketed under brand names such as Biaxin. As a generic medication, it offers patients the same therapeutic benefits and efficacy as its branded counterparts but is often available at a more accessible price point. Its development as a macrolide antibiotic aimed to provide a broader spectrum of activity and improved pharmacokinetic properties compared to earlier agents in the same class.

How Clarithromycin Works

Clarithromycin functions by interfering with the essential processes of bacteria. It targets the bacterial ribosome, specifically the 50S ribosomal subunit. By binding to this subunit, Clarithromycin inhibits the translocation step of protein synthesis, effectively halting the production of vital bacterial proteins necessary for their growth and replication. This bacteriostatic action prevents the bacteria from multiplying. At higher concentrations, Clarithromycin can also be bactericidal, meaning it directly kills the bacteria. Its effectiveness spans a range of Gram-positive and Gram-negative bacteria, as well as atypical organisms like Chlamydia and Mycoplasma. Once ingested, Clarithromycin is well absorbed and distributed throughout the body, reaching concentrations sufficient to combat infection.

Conditions Treated with Clarithromycin

Clarithromycin is approved to treat a range of specific bacterial infections. Its efficacy stems from its ability to inhibit bacterial protein synthesis, thereby controlling or eradicating the causative microorganisms.

• Lower Respiratory Tract Infections: Such as community-acquired pneumonia and acute exacerbations of chronic bronchitis, often caused by bacteria like Streptococcus pneumoniae or Haemophilus influenzae. Clarithromycin's ability to penetrate lung tissue makes it suitable for these conditions.
• Upper Respiratory Tract Infections: Including sinusitis and pharyngitis/tonsillitis, commonly caused by group A Streptococcus. It is an effective alternative for individuals with allergies to penicillin.
• Skin and Soft Tissue Infections: For uncomplicated infections caused by susceptible bacteria like Staphylococcus aureus or Streptococcus pyogenes. It helps to clear the infection and prevent its spread.
• Disseminated Mycobacterial Infections: Clarithromycin is a crucial component in treating infections caused by Mycobacterium avium complex (MAC), particularly in immunocompromised individuals. It plays a role in both treatment and prophylaxis of these opportunistic infections.
• Eradication of Helicobacter pylori: Clarithromycin is often used in a multi-drug regimen, alongside a proton pump inhibitor and another antibiotic (like amoxicillin or metronidazole), to treat H. pylori infections associated with peptic ulcers. This combination therapy aims to achieve complete eradication of the bacteria.

Is Clarithromycin the Right Medication for You?

Clarithromycin generally suits adult patients diagnosed with bacterial infections susceptible to its spectrum of activity. It is particularly useful in cases where alternative antibiotics, such as penicillins, cannot be used due to allergies. Its effectiveness against a broad range of pathogens makes it a versatile choice for common infections like those affecting the respiratory system and skin. Individuals with or at risk of Mycobacterium avium complex (MAC) infections, especially those with compromised immune systems, may find Clarithromycin a vital part of their treatment or preventative management.

However, Clarithromycin is not suitable for everyone. It is contraindicated in patients with a known hypersensitivity to Clarithromycin, other macrolides (like erythromycin or azithromycin), or any of the inactive ingredients in the formulation. Caution is advised, and it may be inappropriate for individuals with specific pre-existing conditions, such as severe liver impairment or certain heart rhythm abnormalities (QT prolongation). A healthcare professional will assess your full medical history to determine if Clarithromycin is the most appropriate and safest treatment option.

Buying Clarithromycin from Our Online Pharmacy

Why Choose Our Service?

For convenient and cost-effective access to your prescribed medications, our online pharmacy service offers a reliable solution. We understand that obtaining essential medicines can sometimes be challenging due to limited availability or high costs. Our platform is designed to streamline this process, ensuring you can securely acquire necessary treatments like Clarithromycin from the comfort of your home.

Quality & Safety Assurance

We are committed to providing authentic and high-quality medications. We partner with licensed international pharmacies to ensure quality and authenticity. This network allows us to source Clarithromycin and other medications from reputable suppliers who adhere to strict regulatory standards for manufacturing and distribution, ensuring that the product you receive meets the same quality benchmarks as locally sourced prescriptions.

Pricing & Access

Clarithromycin, being the generic version of widely prescribed macrolide antibiotics, is often more affordable than its brand-name equivalents. Through our pharmacy service, we aim to pass these savings onto our customers. This allows for more accessible treatment, particularly for those managing chronic conditions or requiring long-term antibiotic therapy, without compromising on efficacy or safety.

Discreet Delivery

Your privacy is paramount. We ensure that all orders are dispatched in plain, unmarked packaging to maintain complete discretion. Whether you choose our express delivery option, which typically arrives within 7 days, or standard airmail delivery, usually taking approximately 3 weeks, your medication will reach you securely and privately.

Use: Dosing, Missed Dose, Overdose

Dosing

The standard dosage for Clarithromycin in adults typically ranges from 250mg to 500mg taken twice daily. The specific dose and duration of treatment depend on the type and severity of the infection being treated. For instance, in the eradication of H. pylori, higher doses might be prescribed for a limited period as part of a multi-drug regimen. Doses are generally taken with or without food. Always follow the dosage instructions provided by your healthcare provider precisely.

Missed Dose

If you miss a dose of Clarithromycin, take it as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to compensate for a missed one. If you have any concerns or are unsure about how to proceed after missing a dose, consult your healthcare provider.

Overdose

If you suspect an overdose of Clarithromycin, seek immediate medical attention. Symptoms of an overdose can include nausea, vomiting, diarrhoea, and abdominal pain. While serious toxicity is rare, it is crucial to receive prompt evaluation and supportive care from a medical professional. Contact your local emergency services or a poison control centre for guidance.

Practical Precautions

• Administration: Tablets can be taken with or without food.
• Alcohol: Avoid consuming alcohol as it may increase the risk of side effects or interfere with the medication's efficacy.
• Operating Machinery: Clarithromycin may cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating heavy machinery until you know how it affects you.

Safety Information

⚠️ Who Should Not Take Clarithromycin

Clarithromycin is contraindicated in several situations:

• Hypersensitivity: Known allergy to Clarithromycin, other macrolide antibiotics (e.g., azithromycin, erythromycin), or any of the inactive ingredients in the formulation.
• Concomitant Medication: Use with certain medications that can cause severe heart rhythm disturbances (e.g., cisapride, pimozide, terfenadine, astemizole), or with certain statins or ergot derivatives.
• Liver Dysfunction: History of severe liver problems, including cholestatic jaundice or hepatic impairment related to previous macrolide use.
• Electrolyte Imbalance: Patients with conditions that may lead to QT prolongation or electrolyte disturbances should use Clarithromycin with extreme caution or avoid it.

Common Side Effects

Many individuals tolerate Clarithromycin well. However, some common side effects may occur, including:

• Gastrointestinal Upset: Nausea, diarrhoea, abdominal pain, and vomiting are among the most frequent complaints. These are often mild and transient.
• Headache: Some users may experience headaches.
• Altered Taste: A metallic or bitter taste in the mouth can occur.

These side effects usually resolve on their own as your body adjusts to the medication. If they persist or become bothersome, consult your healthcare provider.

Serious Side Effects (Seek Immediate Medical Help)

While rare, serious side effects require urgent medical attention:

• Severe Allergic Reactions: Symptoms may include rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.
• Severe Skin Reactions: Such as Stevens-Johnson syndrome or toxic epidermal necrolysis, which can cause blistering, peeling skin, and flu-like symptoms.
• Liver Problems: Signs of liver issues include yellowing of the skin or eyes (jaundice), dark urine, severe stomach pain, or persistent nausea/vomiting.
• Heart Rhythm Abnormalities: Palpitations, irregular heartbeat, or fainting spells can indicate QT prolongation or other cardiac events.
• Clostridium difficile-Associated Diarrhoea (CDAD): Severe or persistent diarrhoea can be a sign of C. difficile infection, which may occur during or after antibiotic treatment.

If you experience any of these symptoms, stop taking Clarithromycin and seek immediate medical help.

Drug & Food Interactions

Clarithromycin can interact with numerous other medications, potentially altering their effectiveness or increasing the risk of side effects. It is crucial to inform your healthcare provider about all medications, supplements, and herbal products you are currently taking.

• CYP3A4 Inhibitors/Inducers: Clarithromycin is metabolized by the CYP3A4 enzyme. It can inhibit this enzyme, increasing levels of drugs metabolized by CYP3A4, such as certain statins (e.g., simvastatin, lovastatin), calcium channel blockers, benzodiazepines, and phosphodiesterase inhibitors. This can lead to toxicity. Conversely, certain drugs can induce or inhibit CYP3A4, affecting Clarithromycin levels and efficacy.
• Colchicine: Concomitant use with Clarithromycin can lead to colchicine toxicity, especially in patients with renal or hepatic impairment.
• Theophylline: Levels of theophylline may be increased.
• Warfarin: Potential for increased anticoagulant effect and bleeding.
• Antifungals: Some azole antifungals may affect Clarithromycin metabolism.
• Grapefruit Juice: While not a direct interaction in the same way as some other macrolides, it is generally advisable to avoid excessive consumption of grapefruit juice with any medication unless specifically cleared by your healthcare provider.

Always discuss potential interactions with your doctor or pharmacist.

Off-Label and Investigational Uses of Clarithromycin

Clarithromycin has been explored for various uses beyond its officially approved indications. These off-label applications are based on clinical observations, laboratory studies, and evidence from peer-reviewed research, but they have not undergone formal regulatory approval for these specific purposes.

• Dental Infections: Clarithromycin may be used to treat certain severe dental abscesses or infections where other antibiotics are not suitable.
• Prophylaxis for Endocarditis: In specific high-risk individuals undergoing certain dental or surgical procedures, Clarithromycin might be considered as an alternative prophylactic agent for endocarditis, especially if beta-lactam allergies are present.
• Acne Vulgaris: Limited studies have investigated the use of oral Clarithromycin for moderate to severe acne, particularly forms that are inflammatory or resistant to other treatments.
• Prophylaxis Against Tuberculosis: In specific clinical settings, Clarithromycin has been studied for its potential role in preventing the reactivation or dissemination of tuberculosis, particularly in immunocompromised patients.

It is critical to understand that off-label prescription and use of Clarithromycin should only occur under the direct supervision of a qualified healthcare professional who can assess the potential benefits against the risks in an individual patient. The efficacy and safety for these non-approved indications may not be as well-established as for its licensed uses.

Storage & Handling

Clarithromycin pills should be stored at room temperature, typically between 15°C to 30°C (59°F to 86°F). Protect them from excessive heat, light, and moisture. Do not store them in the bathroom. Keep the medication in its original, tightly closed container. Always ensure that medication is kept out of reach of children and pets. Check the expiry date on the packaging and do not use the medication beyond this date. If you have expired medication, dispose of it safely and responsibly according to local guidelines, typically by returning it to a pharmacy for disposal.

Frequently Asked Questions

About Using Clarithromycin

• Can I drink alcohol while taking Clarithromycin? It is generally advised to avoid or limit alcohol consumption when taking Clarithromycin. Alcohol can sometimes exacerbate side effects like nausea or dizziness and may potentially affect how well the medication works. Always consult your healthcare provider for personalised advice.

• Is it safe to take Clarithromycin while traveling across time zones? When travelling across time zones, try to maintain your original dosing schedule as closely as possible. If you are unsure how to adjust your timing, consult your doctor or pharmacist. Consistency in dosing is key to effective treatment.

• Can Clarithromycin be taken with dietary supplements? Clarithromycin can potentially interact with certain dietary supplements. It is important to inform your healthcare provider about all supplements you are taking to ensure there are no contraindications or potential interactions that could affect your treatment.

Product Information

• What do Clarithromycin pills look like? Clarithromycin pills are typically white to off-white, elliptical-shaped tablets. The exact appearance, including any markings or coatings, can vary slightly between manufacturers and specific product formulations.

• Are there different types of Clarithromycin pills available? Clarithromycin is available in immediate-release pills (tablets and oral suspension) and extended-release formulations. The immediate-release form is usually taken twice daily, while extended-release versions may be taken once daily. Your prescription will specify which type is appropriate for you.

Safety & Regulations

• Will Clarithromycin show up on a drug test? Clarithromycin is an antibiotic and is not typically screened for on standard drug tests used for illicit substances. However, some specialised forensic or medical tests might detect its presence if specifically analysed for.

• Can Clarithromycin be used during pregnancy? The use of Clarithromycin during pregnancy is generally avoided unless the potential benefits outweigh the potential risks to the foetus. It is classified under pregnancy categories where safety has not been definitively established. Always discuss pregnancy plans or potential pregnancy with your doctor while on this medication.

• Is Clarithromycin safe for elderly patients? Elderly patients may be more susceptible to side effects like QT prolongation or might have impaired kidney or liver function, which could affect drug clearance. Dosing adjustments may be necessary, and careful medical supervision is recommended.

• What are the precautions for patients with kidney impairment? Patients with significantly reduced kidney function may require a lower dose of Clarithromycin or a reduced dosing frequency. Your doctor will assess your kidney function to determine the appropriate dosage and monitor for side effects.

• Can Clarithromycin be crushed or split? Immediate-release Clarithromycin tablets are generally designed to be swallowed whole. Crushing or splitting them may alter the absorption rate or lead to an unpleasant taste. Extended-release formulations should never be crushed or split. Always consult your pharmacist or doctor before altering how you take your medication.

Glossary

Bacteriostatic

A term describing an agent that inhibits the growth or reproduction of bacteria, without necessarily killing them.

Ribosome

A cellular particle made of ribosomal RNA and protein that serves as the site of protein synthesis in the cell.

QT Prolongation

A condition where the heart's electrical recharging phase (repolarization) is longer than normal, which can increase the risk of serious heart rhythm disturbances.

Macrolide

A class of antibiotics characterized by a large macrocyclic lactone ring, which inhibit bacterial protein synthesis.

H. pylori (Helicobacter pylori)

A type of bacteria that can infect the stomach and is a common cause of peptic ulcers.

Disclaimer

The information provided concerning Clarithromycin is intended for educational purposes only and should not be substituted for professional medical advice. All decisions regarding treatment, including the use of Clarithromycin for any medical condition, whether approved or investigational, must be made in consultation with and under the direct supervision of a qualified healthcare professional. We operate on the understanding that all users accessing our services are adults responsible for their own health decisions. Our online pharmacy service facilitates access to Clarithromycin, making it available to individuals who may have difficulty obtaining it through other channels, offering a generic alternative. Consulting with your physician is essential before initiating, altering, or discontinuing any medication regimen.